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. 2011 Oct 17;60(11):2914–2921. doi: 10.2337/db11-0705

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Coablation of Tregs abrogates the diabetes protective effects of selectively eliminating FO B cells in pre-IAA onset NOD mice. Anti-CD20 or control antibody treatment was initiated in 10-week-old NOD female mice typed to be IAA negative, with a subset also injected at 2-week intervals with a CD25-specific antibody to deplete Tregs. Compared with controls, diabetes development was significantly decreased only in NOD mice treated with anti-CD20 alone (P = 0.0175, Kaplan-Meier analyses). T1D, type 1 diabetes.