FIG. 5.

Central SIRT1 is required to regulate the effects of systemic resveratrol. A: Experimental protocol for basal insulin clamp. B: Effect of systemic resveratrol on plasma basal insulin and basal glucose levels. C–F: GIR, glucose production, or glucose uptake after systemic infusion of vehicle or resveratrol with or without IH SIRT1 inhibitor. G–I: Flux through G6Pase, glycogenolysis, and gluconeogenesis after treatment with vehicle, resveratrol, or IH SIRT1 inhibitor. All values are mean ± SEM. *P < 0.05, **P < 0.005 compared with control. For all studies: control, white bar; resveratrol, black bars; resveratrol and SIRT1 inhibitor, striped bars.