TABLE 1.
Demographics and correlations with plasma and CSF FGF21 and the CSF-to-plasma FGF21 (n = 38)
| Variable | Median (interquartile range) | Plasma FGF21 | CSF FGF21 | CSF-to-plasma FGF21 ratio |
|---|---|---|---|---|
| Age (years) | 53.0 (42.0–64.0) | 0.100 | 0.174 | 0.067 |
| BMI (kg/m2) | 26.1 (23.5–30.2) | 0.576* | 0.479* | −0.385† |
| Body weight (kg) | 75.2 (66.3–88.3) | 0.449* | 0.389† | −0.272 |
| Fat mass (kg) | 21.8 (15.6–29.9) | 0.601* | 0.574* | −0.389† |
| Glucose | ||||
| Plasma (mmol/L) | 4.9 (4.6–5.4) | 0.076 | 0.032 | −0.002 |
| CSF (mmol/L) | 3.2 (3.1–3.5) | 0.201 | −0.038 | −0.232 |
| CSF-to-plasma ratio | 0.65 (0.61–0.70) | 0.130 | −0.145 | −0.251 |
| Insulin | ||||
| Plasma (pmol/L) | 64.7 (43.4–110.9) | 0.374† | 0.457* | −0.210 |
| CSF (pmol/L) | 1.8 (1.8–2.3) | 0.142 | −0.065 | −0.157 |
| CSF-to-plasma ratio | 0.029 (0.023–0.045) | −0.205 | −0.417* | 0.066 |
| HOMA-IR | 2.5 (1.6–4.2) | 0.385† | 0.413* | −0.234 |
| Adiponectin | ||||
| Plasma (µg/mL) | 10.6 (8.9–16.0) | −0.341† | 0.132 | 0.371† |
| CSF (ng/mL) | 4.1 (3.0–7.2) | −0.064 | −0.015 | 0.028 |
| CSF-to-plasma ratio | 0.00038 (0.00029–0.00058) | 0.130 | −0.150 | −0.184 |
| FGF21 | ||||
| Plasma (pg/mL) | 153.5 (87.5–290.2) | — | — | — |
| CSF (pg/mL) | 60.9 (55.4–66.9) | 0.430* | — | — |
| CSF-to-plasma ratio | 0.35 (0.16–0.52) | −0.830* | −0.033 | — |
Spearman rank correlation was used for the calculation of associations between variables. P < 0.05 was considered significant.
*P < 0.01.
†P < 0.05.