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. 2011 Jun 8;19(11):1138–1143. doi: 10.1038/ejhg.2011.99

Figure 1.

Figure 1

Bisulphite sequencing analysis of H19DMR in control blastocysts and control sperm (a: sperm from a fertile man; b: pool of sperm from five fertile men), and in arrested embryos and their matching sperm and oocytes (when available, couples 5 and 33). Each line represents a single allele. Black squares indicate a methylated CpG and an open square denotes an unmethylated CpG. Blue lines correspond to alleles exhibiting a nucleotide 6236-A, whereas black lines correspond to alleles carrying a nucleotide 6236-C. In H19DMR, sequence from 6097 to 6330 bp, the SNP A/C, bp 6236, is indicated in blue, whereas the sixth CTCF-binding site is indicated in red. P, preblastocyst; CM, compact morula; M, morula; BC, atypic BC blastocyst; Inline graphic SNP A, bp 6236; ▾ SNP C, bp 6236.