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. 2011 Oct 17;195(2):307–322. doi: 10.1083/jcb.201104053

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© 2011 Perdiguero et al.

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Figure 5. — Early p38-induced IL-1β stimulates the later expression of the antiinflammatory cytokines IL-10 and TGFβ in cultured macrophages. (A) Primary macrophages were cultured in vitro and stimulated with LPS. At the time of stimulation, or after 1.5 h, cells were treated or not treated with SB203580 (SB) for the indicated times. Comparative qPCR analysis. NT, nontreated cells. (B) Primary macrophages were treated with LPS ± SB203580, cycloheximide (CHX), or actinomycin D (Act D). (C) As in B, cells were treated with an IL-1β neutralizing antibody, control IgG antibody, or recombinant IL-1β for 24 h (in this case, in the absence of LPS). Means ± SEM of at least three experiments. *** or ^#, P < 0.001; **, P < 0.01; *, P < 0.05.