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. 2011 Oct 17;195(2):263–276. doi: 10.1083/jcb.201108059

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© 2011 Chen et al.

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Figure 7. — Nonapoptotic function of Bcl-x_L. (A) Two-photon microscopy of bcl-x–deficient cultured neurons was performed as described for Fig. 1 B, except using a flow chamber. The measurements shown begin with the flow of oligomycin-free medium after 40 min of 5 µg/ml oligomycin (n = 4–11 per time point per genotype). Data are presented as the mean ± SD. (B) A model depicting an increase in membrane leak in the absence of Bcl-x_L. M, matrix. (C) Heat ramp cell death assay of yeast strains with mutant ATP2 or FIS1/whi2-1 (Cheng et al., 2008; Teng et al., 2011). Representative images of yeast growth are shown; arrows indicate fivefold dilutions. Data are presented as mean ± SD for four independent strains per plasmid, each tested in duplicate in each of two independent experiments and plotted as the ratio of colony numbers for Bcl-x_L/empty vector (FIS1/whi2, n = 10; ATP2, n = 16). Student’s t test was used; *, P = 5.7 × 10⁻¹⁰.