Table 2.
Change in sleep parameters
| Baseline (n = 21) | 3 Months (n = 17) | P-value | 6 Months (n = 19) | P-value | |
|---|---|---|---|---|---|
| Sleep Disordered Breathing | |||||
| Apnea hypopnea index (events/h) | 43.1 (17.5) | 19.0 (10.7) | < 0.001 | 19.5 (16.7) | < 0.001 |
| Apnea index (events/h) | 4.8 (7.3) | 2.6 (3.4) | 0.26 | 1.3 (2.2) | 0.002 |
| Hypopnea index (events/h) | 38.3 (14.8) | 16.4 (8.8) | < 0.001 | 18.3 (16.0) | < 0.001 |
| Arousal index (events/h) | 43.8 (19.5) | 23.4 (9.6) | 0.015 | 23.5 (15.4) | < 0.001 |
| Respiratory arousal index (events/h) | 31.3 (20.2) | 10.5 (5.8) | < 0.001 | 11.0 (13.8) | < 0.001 |
| Oxygen desaturation index 4% (events/h) | 16.8 (14.4) | 8.0 (7.8) | < 0.001 | 9.1 (16.7) | < 0.001 |
| Sleep Architecture | |||||
| Sleep latency (min) | 17.8 (15.5) | 12.1 (14.1) | 0.14 | 10.1 (9.7) | 0.098 |
| Total sleep time (min) | 340.5 (64.0) | 363.0 (65.7) | 0.43 | 349.5 (57.7) | 0.88 |
| Sleep efficiency (%) | 76.6 (11.3) | 82.5 (12.5) | 0.04 | 81.7 (11.6) | 0.03 |
| Time in N1 (% total sleep time) | 27.4 (10.4) | 17.6 (7.5) | 0.003 | 20.8 (11.5) | 0.003 |
| Time in N2 (% total sleep time) | 47.9 (7.2) | 49.2 (8.5) | 0.96 | 50.6 (9.6) | 0.62 |
| Time in N3 (% total sleep time) | 11.2 (7.7) | 14.8 (9.5) | 0.34 | 11.6 (9.3) | 0.99 |
| Time in REM (% total sleep time) | 13.5 (5.5) | 18.4 (4.4) | 0.006 | 17.0 (5.6) | 0.02 |
All values are mean (± SD).
N, sample size.
P-values are all versus Baseline. Data are also presented as median and ranges in Supplementary Table S1.