Table 3.
Pregnancy outcomes in SLE patients with disease status of SLE at conception
| Activity at conception | p-value | ||||
|---|---|---|---|---|---|
| Stable state | Active state | ||||
| Gestational age at delivery | 38.1±1.8 | 35.0±5.3 | 0.0003 | ||
| Birth weight | 2.85±0.50 | 2.15±0.82 | <0.0001 | ||
| Low birth weight (<2.5 kg) | 28 (24.1) | 26 (57.8) | <0.0001 | ||
| Delivery mode | |||||
| Vaginal delivery | 61 (52.1) | 23 (47.9) | 0.6224 | ||
| Cesarean delivery | 56 (47.9) | 25 (52.1) | |||
| Lupus flare | Yes | Mild | 38 (80.9) | 20 (42.6) | <.0001 |
| Severe | 8 (17.0) | 26 (55.3) | |||
| No | 81 (63.8) | 10 (17.6) | |||
| Pregnancy loss | 11 (8.7) | 19 (33.9) | <.0001 | ||
| Oligohydramnios | 4 (3.8) | 1 (2.1) | 1.0000 | ||
| PPROM | 5 (4.7) | 0 (0.0) | 0.3253 | ||
| PIH | 13 (12.3) | 12 (25.5) | 0.0422 | ||
| IUGR | 18 (17.0) | 6 (12.8) | 0.5230 | ||
| PIH+IUGR | 3 (2.8) | 14 (29.8) | <.0001 | ||
| Preterm birth | 22 (18.8) | 27 (55.1) | <0.0001 | ||
| Low apgar score (< 7 at 1 min) | 10 (8.6) | 17 (37.0) | <0.0001 | ||
| Low apgar score (< 7 at 5 min) | 4 (3.5) | 11 (23.9) | 0.0002 | ||
| Congenital anomaly | 3 (4.8) | 3 (10.3) | 0.3750 | ||
By t-test, chi-square test, or Fisher's exact test
Pregnancy loss includes miscarriage, still birth, and neonatal death; PPROM: Preterm premature rupture of membrane; PIH: Pregnancy induced hypertension; IUGR: Intrauterine growth restriction