Fig. 3.

Comparison of thyroid weight among mice with indicated genotypes. (A) Thyroids were dissected from adult mice (males and females 3–5 mo old). Ratios of tissue mass vs. body weight were determined (thyroid weight/body weight). The data are expressed as mean ± SEM (n = 15–20) with P value indicated. (B) Representative example of a smaller-sized thyroid of a Thrb^PV/PV Ncor1^ΔID/ΔID mouse compared with the thyroid of a Thrb^PV/PVNcor1^+/+ mouse. The thyroids in these mice are outlined. (C) Representative histological features of the thyroid gland of Thrb^PV mice with or without Ncor1^ΔID. Hematoxylin and eosin staining of thyroids from 3- to 5-mo-old (a) WT, (b) Thrb^PV/PV Ncor1^+/+, and (c) Thrb^PV/PV Ncor1^ΔID/ΔID mice. All panels are shown with the same magnification.