Fig. 6.
Effect of NCOR1ΔID on PV-mediated gene expression patterns is T3-target gene-dependent. (A) Comparison of the expression of the TSH β-subunit gene (Tshb) and α-glycoprotein common subunit (Cga) in the pituitary of ThrbPV mice with or without NCOR1ΔID. (B) Comparison of the expression of malic enzyme (Me1), cholesterol 7α hydroxylase1 (Cyp7a1), and CCAAT/enhancer-binding protein α (C/ebpα) mRNA in the liver of ThrbPV mice. Relative quantification of each target mRNA was determined by arbitrarily setting the control value of WT mice as 1. The level of expression was normalized by signals obtained using specific primers for mouse Gadph. The data are expressed as mean values ± SEM (n = 6–9) with P values shown.