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nNOS regulates HIF-α–dependent genes in acute anemia, but not in hypoxia. HIF-α–dependent mRNA levels were measured in brain samples of WT (open bars) and nNOS−/− in anemic (A–D; filled bars) and hypoxic mice after 6 h (E–H; gray bars) (n = 6 per group). Relative mRNA levels were normalized to the respective baseline. *P < 0.05 vs. baseline. #P < 0.05 vs. WT.
