Fig. 3.

CD8⁺ T cells primed by indirectly activated APCs are not protective. Chimeric mice were immunized as in Fig. 2 and challenged with B16-OVA tumors 2 wk later. Eighteen days after tumor challenge the lungs were analyzed. (A) Pseudometastases burden per lung, (B) number of tumor cells per lung, (D) and absolute number of OT-I cells per lung are shown. (C) Representative lungs of control and test chimeric mice immunized as indicated are shown. Pooled data from two of three independent experiments are shown (n = 7–10, A–D).