Table 1.
Date of mice used in the present study
Organ involvement at death |
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Max. leukemic cells in PB |
BM invasion |
Extramedullary tumor |
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Mouse no. | Survival, d | % | Day | Femoral | Vertebral | Expansion from BM | Isolated from BM | Cause of death |
MYL 1 | 31 | 36.8 | 14 | — | — | — | Mediastinum | D |
MYL 2 | 35 | 40.0 | 18 | — | — | — | Abdominal cavity | D |
MYL 3 | 38 | 53.6 | 18 | — | — | Lower jaw | s.c. Tissue abdominal cavity | D |
MYL 4 | 42 | 52.9 | 21 | — | — | — | Abdominal cavity axillary LN | D |
MYL 5 | 45 | 38.0 | 28 | — | — | — | Abdominal cavity s.c. tissue | D |
MYL 6 | 48 | 42.6 | 18 | + | + | — | s.c. Tissue abdominal cavity | D |
MYL 7 | 48 | 42.0 | 21 | — | — | — | s.c. Tissue abdominal cavity, soft tissue around the testis | D |
MYL/G3 1 | 57 | 73.3 | 14 | + | + | Sacrum | — | B |
MYL/G3 2 | 80 | 57.7 | 71 | + | + | Sacrum | — | E |
MYL/G3 3 | 80 | 50.0 | 48 | + | + | — | — | E |
MYL/G3 4 | 80 | 54.0 | 71 | + | + | Sacrum | — | E |
MYL/G3 5 | 80 | 48.0 | 18 | + | + | Sacrum, right femur | — | E |
MYL/G3 6 | 80 | 48.0 | 68 | + | + | — | — | E |
MYL/G3 7 | 80 | 57.14 | 24 | + | + | — | — | E |
B, Loss of >10% body wight; D, deterioration caused by tumor; E, euthanasia; LN, lymph node; Max.: maximum.