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. 2011 Oct 19;6(10):e25974. doi: 10.1371/journal.pone.0025974

Table 3. Median single-dose (SD) PK parameters (all data points collected during the study).

Analyte, Matrix N N(>BLQ ) Samples(>BLQ/Total #) Cmax (ng/mL) Tmax (hr) AUC0–24 h (hr*ng/mL) C24 h (ng/mL)
SD SD SD SD
TFV BP (IQR) 48 48 313/392 (80%) 4.0 (1.5–9.1) 4 (2–6) 36.4 (14.0–73.3) 0.3 (0.3–0.5)
TFV CVF 45 45 52/52 (100%) 1.9×106 4 20.7×106 0.1×106
TFV Vaginal Tissue 33 333 72/72 (100%) 2.2×105 2 64.0×104 0.7×104
TFV-DP ECC 48 39 42/57 (74%) 7.5×105 4 47.4×105 0.8×105
TFV-DP Vaginal Tissue 33 154 36/72 (50%) 3.8×103 1 12.4×103 n/a
TFV-DP ECC1 48 39 42/57 (74%) 33.6×104 4 212.2×104 3.5×104
TFV-DP Vaginal Tissue2 33 15 36/72 (50%) 1.7×103 1 5.6×103 n/a
1

Cmax and C24 h in fmol/106 cells; AUC0–24 h in hr * fmol/106 cells.

2

Cmax and C24 h in fmol/0.2 µL; AUC 0–24 h in hr * fmol/0.2 µL.

3

Thirty-six data points contributed to the TFV tissue analysis.

4

Fifteen data points out of a potential 36 contributed to the TFV-DP tissue analysis.