Figure 9. Effects of cysteamine in TrkB knockout mice on anxiety-like behaviors as measured in the (A) Open Field test, (B-C) Light/Dark test, (D) Elevated Plus Maze Maze test and (E) Tail Suspension Test.

TrkB knock out (KO) and wild type (WT) male mice were treated for 3 weeks with vehicle (water) or cysteamine (CYS; 150 mg/kg/day). (A) Mean total of the time spent in the center for the entire session, (B) % of the time-spent in the lit area, (C) % of the time-spent in the dark area, (D) % of the time in open arms, and (E) the immobility score (in seconds). Values are mean ± SE (n = 6 mice per group). Bonferroni's post hoc test. *p<0.05 versus vehicle.