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. 2011 Oct 19;6(10):e26087. doi: 10.1371/journal.pone.0026087

Figure 1. Comparison of hemorrhagic transformation 24 h after MCAO in mice with different antithrombotic pretreatment.

Figure 1

A) Comparison of HT volumes in mice who received i.v. thrombolysis with 10 mg/kg human recombinant t-PA directly prior to reperfusion (middle, n = 5) and mice who were effectively anticoagulated to an INR of approximately 3 at the onset of 3 h MCAO (right, n = 4 after exclusion of outlier, see Fig. S1) with mice who underwent 3 h MCAO without any treatment (left, n = 5). Hematoma volume was determined by a hemoglobin assay. Data are depicted as box and whiskers plots showing the 25 to 75 interquartile range and the extreme values. Statistical significance was analyzed with ANOVA and bonferroni correction for multiple testing. *** p<0.001. B) Neuroscores were assessed for statistical significance with a Kruskal-Wallis test and Dunn's correction. Differences between groups were not significant (median values 4, 4 and 5).