Figure 9.

Representative histopathologic changes observed in pulmonary vascular lesions in SHIV-nef–infected macaques. Sections of lungs from macaquesinfected with the chimeric SHIV-nef virus (SHIV-A) or a non-chimeric SIV virus (SIV-F) were stained using H&E and imaged using a ×40 objective in visiblelight. Elastin autofl uoresence was simultaneously imaged in green and the visible light and autofl uoresence images merged. Representative images showing neointimal proliferation (Prolif), obliterative (Oblit) and plexiform (Plex) lesions are illustrated. Side sets on the right show higher magnifi cation views of the boxed areas within each panel in the middle column. (Adapted from ref. 2.)