Table 5.
Genetic screening of the complement system
| Gene | Location | Method of choice for mutation screening | Number of exons |
|---|---|---|---|
| CFH | RCA, Chr 1q32 | Direct sequencing analysis | 22 |
| CFI | Chr 4q25 | Direct sequencing analysis | 13 |
| MCP | RCA, Chr 1q32 | Direct sequencing analysis | 14 |
| C3 | Chr 19p13.3 | Direct sequencing analysis | 42 |
| CFB | Chr 6p21.3 | Direct sequencing analysis | 18 |
| THBD | Chr 20p11.2 | Direct sequencing analysis | 1 |
Chr, chromosome; CFH, factor H; CFHR1, factor H-related protein 1; CFI, factor I; MCP, membrane cofactor protein; CFB, factor B; THBD, thrombomodulin.