Figure 1. Pept1^−/− animals on high-protein diet show major changes in metabolic parameters.

Metabolic parameters of male mice on low-protein (LP  = 8% protein energy), control (C  = 21% protein energy) and high-protein (HP = 45% protein energy) diet were determined in Pept1^+/+ (wt) and Pept1^−/− (ko) animals. During 5 days on the different diets, food intake (A), weight (B), and feces excretion (C) were determined (n = 10). Data are presented as mean±SEM. *P<0.05, ^$P<0.01, ^§P<0.001.