A–C: SHRSP (animal 2, 34 weeks old) with cerebral microbleeds. D–F: SHRSP (animal 4, 31 weeks old) with cerebral infarctions containing small vessel occlusions. There is a strong correlation between an advanced kidney pathology, i.e. peritubular aggregations of erythrocytes, protein cylinders and different stages of glomerulosclerosis with cerebral infarctions accompanied by either microbleeds (here hippocampus, C) or small vessel occlusions with surrounding necrotic tissue (F). A
&
D: kidney medulla, B
&
E: kidney cortex, peritubular aggregations of erythrocytes are marked by black dashed lines (A
&
D), protein cylinders by white asterisks (A, B
&
D). Different stages of glomerulosclerosis are marked in B
& E (o, x; see also
Figure 5
). In addition kidney vessels are affected by thrombotic microangiopathy (+
in
B). B corresponds to
Figure 5
E. A002-34: animal number 2, 34 weeks old.