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. 2011 Oct 21;6(10):e26287. doi: 10.1371/journal.pone.0026287

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Schreiber et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Regression lines. The regression lines in Figure 6 demonstrate the positive association between the severity of the kidney pathology (y-axis) and the age (x-axis) in SHRSP (blue) and Wistar (green) group. The extent of peritubular aggregated erythrocytes and the extent of tubular protein cylinders is separately assessed in the kidney medulla and cortex and is captured in a semiquantitative manner (0–3, y-axis; see also Figure 1 and Material and Methods, kidney). Note the increase of the severity of the kidney pathology with age in SHRSP (cortex: erythrocyte aggregations, regression coefficient [rc] 0.042, CI 0.019-0.065, p = 0.001; protein cylinders, rc 0.04, CI 0.025–0.055, p = <0.001; medulla: erythrocyte aggregations, rc 0.074, CI 0.057–0.090, p = <0.001; protein cylinders, rc 0.093, CI 0.079–0.107, p = <0.001) and to a lesser extent in the Wistar group (cortex: erythrocyte aggregations, rc 0.07, CI -0.001–0.015, p = 0.08; protein cylinders, rc 0.008, CI 0.005–0.011, p = <0.001; medulla: erythrocyte aggregations, rc 0.024, CI 0.014–0.034, p = <0.001; protein cylinders, rc 0.047, CI 0.033–0.061, p = <0.001) resulting in significant group differences (cortex: erythrocyte aggregations p = 0.045, protein cylinders p = 0.004; medulla: erythrocyte aggregations p = <0.001, protein cylinders p = <0.001).