Figure 1. The antiallodynic and antihyperalgesic effects of JWH-015.

Effects of the subplantar administration of different doses (logarithmic axis) of JWH-015 or vehicle on the mechanical allodynia (A) and thermal hyperalgesia (B) induced by CFA, in the ipsilateral paw of WT mice at 10 days after their injection. JWH-015 was administered 20 min before starting behavioral testing. Data are expressed as mean values of the von Frey filaments strength (g) for mechanical allodynia and as the paw withdrawal latency (s) for thermal hyperalgesia ± SEM (5–6 animals per dose). In both tests, for each dose, ** p<0.01 and *** p<0.001 denotes significant differences between JWH-015 and vehicle treated animals (Student's t test).