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. 2011 Oct 21;6(10):e26688. doi: 10.1371/journal.pone.0026688

Figure 5. The antiallodynic and antihyperalgesic effects of JWH-015 in WT and NOS1-KO mice.

Figure 5

Effects of the subplantar administration of 150 µg of JWH-015 or vehicle in the contralateral and ipsilateral paw withdrawal latencies to a mechanical (A) or thermal (B) stimulus in WT and NOS1-KO mice, at 10 days after CFA injection. Data are expressed as mean values of the von Frey filaments strength (g) for mechanical allodynia and as the paw withdrawal latency (s) for thermal hyperalgesia ± SEM (5–6 animals per group). For each test, *** p<0.001, indicates significant differences vs. their contralateral paw (paired Student's t test), + indicates significant differences as compared with the ipsilateral paw of vehicle treated group (p<0.05, one way ANOVA followed by the Student-Newman-Keuls test) and # indicates significant differences as compared with the ipsilateral paw of WT group treated with JWH-015 (p<0.05, one way ANOVA followed by the Student-Newman-Keuls test).