Table 1. Identified mutations that suppress enhanced morphological developments of the homozygous hog1Δ/hog1Δγstrain.
| Gene | CCM | IG | FG | Description of gene product | Reference |
| ADE6 | – – | – – | – | Formylglycinamidine-ribonucleotide (FGAM)-synthetase | This study |
| AMN1 | – – | – | – | Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability | [15] |
| ATO2 | – – | – – | + | Putative transmembrane protein involved in export of ammonia | This study |
| CLN1 | – – | – | – – | G1 cyclin involved in regulation of the cell cycle | [16], [23] |
| DHH1 | – – | – – | – | Cytoplasmic DExD/H-box helicase | [24] |
| FLO8 | – – | – – | – – | Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth | [15], [20] |
| GCN2 | – – | – | + | Protein kinase that phosphorylates the alpha-subunit of translation initiation factor eIF2 | [19] |
| HIR2 | – – | – | – | Subunit of the HIR complex | [15] |
| HIR3 | – – | – | – | Subunit of the HIR complex | This study |
| IES1 | – | + | – | Subunit of the INO80 chromatin remodeling complex | This study |
| IMP2′ | – | – | – | Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage | This study |
| KRE11 | – | – | + | Subunit of the TRAPP II (transport protein particle) complex | This study |
| KSS1 | – – | – – | – – | Mitogen-activated protein kinase involved in filamentous growth and pheromone response | [21] |
| MSN1 | – | – – | – | Transcriptional activator involved in invertase expression and invasive growth/pseudohyphal differentiation | [15], [26] |
| MTC5 | – – | – – | – – | Subunit of the SEA (Seh1-associated) complex | This study |
| RAD1 | – – | – – | – | Single-stranded DNA endonuclease | This study |
| RAD24 | – | – | + | Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints | This study |
| RAS2 | – – | – – | – – | GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth | [15], [16] |
| RDI1 | – | + | – | Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42 | [22] |
| RIM9 | – – | – – | – – | Protein of unknown function involved in the proteolytic activation of Rim101p in response to alkaline pH | [15], [27] |
| SHE10 | – – | – | + | Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function | This study |
| SIR3 | – – | – – | – | Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails | This study |
| SLP1 | – | – | – | Member of the SUN-like family of proteins | This study |
| SPT2 | – | – – | – | Protein involved in negative regulation of transcription | This study |
| STE7 | – – | – – | – – | MAPK kinase involved in pheromone response and pseudohyphal/invasive growth | [16], [21] |
| TCO89 | – | – | – | Subunit of TORC1, a complex that regulates growth in response to nutrient availability | This study |
| TEC1 | – – | – – | – – | Transcription factor required for haploid invasive and diploid pseudohyphal growth (TEA/ATTS family) | [14], [15], [16] |
| UBP6 | – | – | – | Ubiquitin-specific protease | This study |
| YDR306C | – – | – – | + | F-box protein of unknown function | This study |
| YHR177W | – – | – – | – – | Putative protein of unknown function | This study |
CCM: complex colony morphology, IG: invasive growth, FG: filamentous growth.
– –: severe defect, –: intermediate defect, +: similar to control (hog1Δ/hog1Δ).