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. 2011 Oct 21;6(10):e26590. doi: 10.1371/journal.pone.0026590

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(A) BAL analysis found significantly higher concentration of total protein and numbers of monocytes, lymphocytes, phagocytic macrophages, and epithelial cells in Nrf2^-/- mice at 9 and/or 11 wk after urethane treatment. Neutrophilic myeloperoxidase (MPO) activity in BAL fluids was also significantly higher in Nrf2^-/- mice than in Nrf2^+/+ mice. Mean±SD are presented (n = 3/group for vehicle, n = 5−9/group for urethane). *, p<0.05 vs. genotype-matched controls. +, p<0.05 vs. treatment-matched Nrf2^+/+ mice. (B) Necrotic lung cell lysis and death was assessed by lactate dehydrogenase (LDH) activity in aliquots of BAL fluids using a colorimetric assay. Mean±SD are presented (n = 3/group for vehicle, n = 5−9/group for urethane). *, p<0.05 vs. genotype-matched controls. +, p<0.05 vs. treatment-matched Nrf2^+/+ mice. (C) Percent whole body weight changes monitored during and after saline or urethane treatment. Mean±SD are presented (n = 9−24 in vehicle groups, n = 64−82 in urethane groups). *, p<0.05 Nrf2^+/+ saline-treated vs. urethane-treated mice (p<0.05). #, p<0.05 Nrf2 ^-/- saline-treated vs. urethane-treated mice. +, p<0.05 urethane-treated Nrf2^+/+ mice vs. urethane-treated Nrf2^-/- mice (p<0.05).