Table 2. Representative lung tumor gene transcripts from a total of 376 that were significantly (p<0.01).
| GI Accession | Gene Symbol | Gene Description | Major Gene Ontology (GO) Categories | Cluster (Figure 7C) |
| Cell cycle, Cell growth and proliferation, Cancer | ||||
| NM_016904 | Cks1b | CDC28 protein kinase 1b | cell cycle, cell division | 0 |
| NM_007631 | Ccnd1 | cyclin D1 | re-entry into mitotic cell cycle, cell cycle | 2 |
| NM_013737 | Pla2g7 | phospholipase A2, group VII | inflammatory response, lipid catabolic process | 0 |
| NM_009367 | Tgfb2 | transforming growth factor, beta 2 | angiogenesis, axon guidance, blood vessel development | 0 |
| NM_028618 | Dmkn | dermokine | cell differentiation | 3 |
| NM_011176 | St14 | suppression of tumorigenicity 14 | proteolysis, cell migration | 2 |
| NM_027950 | Osgin1 | oxidative stress induced growth inhibitor 1 | cell differentiation, regulation of cell death | 3 |
| Organismal injury and abnormality, Thiol and xenobiotic metabolism, Tumor morphology | ||||
| NM_010358 | Gstm1 | glutathione S-transferase, mu 1 | glutathione metabolic process | 0 |
| NM_013701 | Ugt1a1 * | UDPglucuronosyltransferase 1 family, polypeptide A1 | transferase activity | 3 |
| NM_008012 | Akr1b8 | aldo-keto reductase family 1, member B8 | oxidation reduction | 1 |
| NM_030677 | Gpx2 | glutathione peroxidase 2 | response to oxidative stress | 0 |
| NM_181415 | Atrnl1 * | attractin like 1 | G-protein coupled receptor protein signaling pathway | 0 |
| NM_027988 | Noxo1 | NADPH oxidase organizer 1 | superoxide metabolic process, cell communication | 0 |
| NM_172442 | Dtx4 | deltex 4 homolog (Drosophila) | Notch signaling pathway | 1 |
| NM_010215 | Il4i1 | interleukin 4 induced 1 | aromatic amino acid family metabolic process, regulation of Rab GTPase activity, oxidation reduction | 0 |
| Cell-To-Cell Signaling and Interaction, Tissue Development, Cell morphology | ||||
| NM_011923 | Angptl2 | angiopoietin-like 2 | signal transduction | 2 |
| NM_008176 | Cxcl1 | chemokine (C-X-C motif) ligand 1 | cellular process, immune response, inflammatory response | 0 |
| NM_010196 | Fga | fibrinogen alpha chain | signal transduction, blood coagulation, platelet activation, protein polymerization | 0 |
| NM_010576 | Itga4 | integrin alpha 4 | blood vessel remodeling, cell adhesion, cell migration | 0 |
| Cardiovascular system development and function, Gene expression | ||||
| NM_008124 | Gjb1 | gap junction membrane channel protein beta 1 | cell communication, cell-cell signaling | 0 |
| NM_033601 | Bcl3 | B-cell leukemia/lymphoma 3 | B cell and follicular dendritic cell differentiation | 0 |
| NM_027286 | Ace2 | angiotensin I converting enzyme 2 | regulation of systemic arterial blood pressure by renin-angiotensin, proteolysis | 3 |
| NM_080457 | Muc4 | mucin 4 | cell adhesion, cell-matrix adhesion | 0 |
| NM_009841 | Cd14 | CD14 antigen | immune response, inflammatory response | 3 |
| NM_009330 | Hnf1b | HNF1 homeobox B | regulation of transcription, DNA-dependent | 3 |
| NM_010807 | Marcksl1 | MARCKS-like 1 | positive regulation of cell proliferation | 0 |
| NM_011340 | Serpinf1 | serine (or cysteine) peptidase inhibitor, clade F, member 1 | negative regulation of angiogenesis, positive regulation of neurogenesis | 0 |
| Carbohydrate and lipid metabolism, Small molecule biochemistry | ||||
| NM_019395 | Fbp1 | fructose bisphosphatase 1 | glycolysis and gluconeogenesis | 0 |
| NM_008412 | Ivl | involucrin | keratinocyte differentiation, keratinization, | 0 |
| NM_022411 | Slc13a2 | solute carrier family 13 member 2 | sodium ion transport (sodium-dependent dicarboxylate transporter), | 1 |
| NM_019588 | Plce1 | phospholipase C, epsilon 1 | activation of MAPK activity, lipid metabolic process | 1 |
| NM_25374 | Glo1 | glyoxalase 1 | anti-apoptosis, carbohydrate metabolic process | 0 |
| NM_153133 | Rdh9 | retinol dehydrogenase 9 | retinoid metabolic process, steroid metabolic process | 0 |
| NM_018737 | Ctps2 | cytidine 5'-triphosphate synthase 2 | pyrimidine nucleotide biosynthetic process, glutamine metabolic process | 0 |
| Others | ||||
| NM_203320 | Cxcl3 | chemokine (C-X-C motif) ligand 3 | chemotaxis, inflammatory response | 3 |
| NM_021564 | Fetub * | fetuin beta | FXR/RXR activation signaling, regulation of the insulin and hepatocyte growth factor receptors | 0 |
*
Genes also significantly different between Nrf2+/+ and Nrf2-/- mice at 12 wk after urethane treatment.
varied between Nrf2+/+ and Nrf2-/- mice at 22 wk after urethane.