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. Author manuscript; available in PMC: 2011 Oct 22.
Published in final edited form as: Biochem J. 2010 Sep 1;430(2):199–205. doi: 10.1042/BJ20100814

Figure 2. Survivin cytoprotection involves a pathway of cytoplasmic-mitochondrial shuttling and intermolecular cooperation with XIAP.

Figure 2

A pool of survivin is recruited to mitochondria, mostly of tumor cells and released in the cytosol in response to cell death stimuli. Mitochondrially released survivin forms a complex with XIAP that is negatively regulated by protein kinase A (PKA) phosphorylation of survivin on Ser20, and results in increased XIAP stability against proteasomal degradation, enhanced gene expression, i.e. NF-κB, and synergistic inhibition of effector and initiator caspases (a schematic diagram of caspase 9 is shown).