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. Author manuscript; available in PMC: 2011 Oct 22.
Published in final edited form as: Biochem J. 2010 Sep 1;430(2):199–205. doi: 10.1042/BJ20100814

Figure 3. Role of survivin in the cellular stress response.

Figure 3

The various functional motifs in survivin are indicated, including the binding sites for protein partners, XIAP (residues 15-38), Hsp90 (residues 79-87), polymerized microtubules (residues 99-142), and AIP (residue 142), and the position of experimentally validated phosphorylation sites for PKA (Ser20) p34cdc2/Cdk1 (Thr34) and Aurora B (Thr117). The survivin binding site for Hsp60 has not yet been identified. Formation of complexes between survivin and molecular chaperones Hsp60, Hsp90 and AIP has been associated with increased survivin stability against proteasomal degradation, nuclear and mitochondrial subcellular trafficking, and inhibition of apoptosis.