TABLE 2.

Pharmacokinetic parameter estimates for tacrolimus in Native American patients

	NONMEM Parameter Estimates						Secondary (Calculated) Parameters
	CL/F	V/F	Q/F	Vss/F	ka	tlag	V2/F	t1/2,α	t1/2,β
	l/h	liter	l/h	liter	hr−1	hr	liter	hr	hr
Population estimate	10.1	73.3	27.1	462	1.38	0.573
Interindividual variability	43.5%	36.9%	50.4%	n.e.	46.0%	13.3%
Mean estimate	11.1	71.5	30.3	462	1.55	0.613	391	1.18	40.2
S.D.	5.53	18.6	13.2	n.e.	0.641	0.149	18.6	0.416	15.7

n.e., not estimated.