TABLE 3.

Comparative tacrolimus oral clearance estimates

Clearance estimates are provided as mean ± S.D., where S.D.s were provided in the reference study.

Group	Patient Type	Clearance/F	Clearance/F
		l/h	l · h−1 · kg−1
Native American, n = 24	Renal transplant	11.1 ± 5.53	0.139 ± 0.072
White/African/Oriental, n = 17	Renal transplant		0.405 (Scholten et al., 2005)
Australian, n = 70	Renal transplant	33.0 ± 11.3 (Staatz et al., 2002)
French, n = 32	Renal transplant	28 (Benkali et al., 2009)
Japanese, n = 39	Renal transplant	25.1 ± 9.2–35.0 ± 13.3, depending on CYP3A5 genotype (Tada et al., 2005)
Japanese, n = 30	Renal transplant		0.467 ± 0.176–0.644 ± 0.226, depending on CYP3A5 genotype (Tsuchiya et al., 2004)
Blacks, n = 13	Renal transplant		1.0 (Fitzsimmons et al., 1998)
Nonblacks, n = 41	Renal transplant		0.47 (Fitzsimmons et al., 1998)
African American, n = 10	Healthy		0.37 (Mancinelli et al., 2001)
White, n = 12	Healthy		0.25 (Mancinelli et al., 2001)
Latin American, n = 12	Healthy		0.31 (Mancinelli et al., 2001)