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. 2011 Nov;80(5):920–929. doi: 10.1124/mol.111.074195

Fig. 7.

Fig. 7.

JNK activation requires functional KOPr. A, untransfected HEK293 cells were treated with nor-BNI, JDTic, or FP3FBZ (10 μM) for 60 min. pJNK-ir was determined by Western blot of cell lysates. Results were analyzed by one-way ANOVA and were insignificant. B, KOPr(+/+) and KOPr(−/−) mice were administered saline, JDTic (10 mg/kg i.p.), or FP3FBZ (50 mg/kg i.p.) and spinal cord homogenates were prepared 60 min later. pJNK-ir was determined by Western blot. Results were analyzed by two-way ANOVA with Bonferroni post hoc comparisons. [**, p < 0.01; ***, p < 0.001 compared with saline controls; ###, p < 0.001 compared with KOPr(+/+) controls].