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Receptor desensitization in the presence of ACh or nicotine. The cells were exposed to 30 s pulses of 1 mM ACh (A) or 100 μM nicotine (B). The inclusion of the α5 subunit reduced the rate of desensitization in the presence of nicotine but was without effect when the receptors were activated by ACh. The summary of the analysis is given in Table 3.
