Skip to main content
. 2011 Sep 22;25(11):1849–1857. doi: 10.1210/me.2011-1081

Fig. 2.

Fig. 2.

Androgen dependency of PSA-CreERT2-mediated genetic marking. A, Schematic diagram showing possible outcomes of lineage marking of cells in testis-intact and castrated PSA-CreERT2/R26R LacZ mice. B, TAM induction of genetic marking in testis-intact and castrated PSA-CreERT2/R26R LacZ mice. TAM was injected 3 wk after Cx (Cx-TAM) along with testis-intact control (Intact-TAM) mice. To verify the transient nature of TAM induction, Cx-TAM-2 wk-T and Cx-TAM-4 wk-T groups were generated by implanting testosterone pellets into Cx-TAM mice 2 or 4 wk after the TAM induction. Mice were killed 10 d after TAM injection in Cx-TAM and Intact-TAM groups or 10 d after the testosterone replacement in Cx-TAM-2 wk-T and Cx-TAM-4 wk-T groups. Scale bars, 200 μm. T, Testosterone.