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. 2011 Jan 19;152(3):967–978. doi: 10.1210/en.2010-0709

Fig. 2.

Fig. 2.

Investigation of the HPA axis. A and B, Symbols represent individual mice [control (circles) and Magel2-null (squares)] with the median and interquartile range shown; n = 7–14 per group. Posttreatment serum corticosterone levels were compared with basal levels within sex and genotype by nonparametric Mann-Whitney test. As expected, corticosterone levels were lower after dexamethasone (dexa) in both sexes of control mice, measured 4 h after injection [*, P < 0.001; U = 0 (male) and U = 21 (females)]. Corticosterone levels were also lower after dexamethasone in male Magel2-null mice (**, P < 0.001; U = 0). However, corticosterone levels were not lower after dexamethasone treatment in female Magel2-null mice [not significant (n.s.)]. C, Corticosterone levels were significantly reduced by metyrapone (Met.) injection measured after 1 h, in female mice of both genotypes (*, P < 0.05). D, Baseline ACTH levels were higher in female Magel2-null mice compared with control (Student's t test; *, P < 0.02). ACTH levels increased significantly in female mice 6 h after metyrapone injection, compared with baseline levels within each genotype (#, P < 0.001).