Table 1.
Subject baseline characteristics.
| CTL (n=16) | No-Em (n=8) | EM (n=14) | ANOVA | No-EM vs EM | |
|---|---|---|---|---|---|
| Age | 53 ± 7.4 | 56 ± 5.9 | 61 ± 9.5 | 0.012 | n.s. |
| Gender | M(8), F(8) | M(2), F(6) | M(5), F(9) | - | - |
| Height (inches) | 68 ± 3.6 | 67 ± 3.6 | 66 ± 3.6 | 0.693 | - |
| Weight (LBS) | 165 ± 35 | 175 ± 35 | 189 ± 47 | 0.466 | - |
| BMI | 25.7 ± 6.1 | 27.2 ± 3.8 | 30.0 ± 6.6 | 0.146 | - |
| Race | C(14) | C(7) | C(14) | - | - |
| AA(2) | A(1) | - | - | ||
| Hypertension | 1/16 | 2/8 | 6/14 | - | - |
| Hyperlipidemia | 0/16 | 0/8 | 3/14 | - | - |
| Atherosclerosis | 0/16 | 0/8 | 2/14 | - | - |
| Cirrhosis | 0/16 | 0/8 | 0/14 | - | - |
| Renal Failure | 0/16 | 0/8 | 0/14 | - | - |
| Diabetes | 0/16 | 0/8 | 2/14 | - | - |
| Cigarette (pk-yr) | 0 | 28 ± 6 | 32 ± 11 | <0.001 | n.s. |
| FEV1/FVC | 0.81 ± 0.06 | 0.82 ± 0.04 | 0.57 ± 0.12 | <0.001 | <0.001 |
| %FEV1 | 97 ± 11 | 101 ± 7 | 72 ± 30 | <0.001 | <0.001 |
| %FVC | 99 ± 12 | 102 ± 7 | 91 ± 23 | 0.021 | n.s. |
| %DLCO | - | 94 ± 5 | 61 ± 13 | - | <0.001 |
All values are mean ± standard deviation. CTL = healthy subjects without smoking. No-EM = Subjects with significant cigarette smoking history (greater than 20 pack-year) but without emphysema by PFT. EM = Subjects with significant cigarette smoking history (greater than 20 pack-year) and with emphysema by PFT. M = male. F = female. Cigarette = number of cigarette pack per day x number of years smoked. FEV1 = Forced Expiratory Volume in 1 second. FVC = Functional Vital Capacity. %FEV1 = Percentage predicted FEV1by the third National Health And Nutrition Survey. %FVC = Percentage predicted FVC by the third National Health And Nutrition Survey. %DLCO = Percentage predicted by the European Community for Coal and Steel (ECCS) 1993 reference. n.s. = p value not significant (greater than 0.05).