Table 1.
Analysis of variance (ANOVA) of microarray data: genotype (Euploids versus Ts65Dn mice) and treatment (Vehicle versus α5IA-treated) were the two main factors. Three-copy genes and IEGs were analyzed separately.
| Analysis of variance (ANOVA) of microarray data | ||||
|---|---|---|---|---|
| Total | Genotype-modulated genes | Treatment-modulated genes | Interaction-modulated genes | |
| All genes | 13024 | 848 | 781 | 1260 |
| 3N genes | 56 | 6 | 3 | 5 |
| Genes | GART, Ifnar-2, Kcnj6, Itsn1, Hlcs, and Sod1 | App, Kcnj6, and Sod1 | Cbr1, Gabpa, 4931408A02Rik, Hmngn1, and Pcp4 | |
| IEGs and BDNF | 16 | 5(***) | 3(*) | 1 |
| Genes | BDNF, Cox2, Homer1, GS2, and Arc | Fos, Egr2, and BDNF | BDNF | |