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. 2011 Oct 19;2012:618608. doi: 10.1155/2012/618608

Figure 1.

Figure 1

Preventive and therapeutic effects of polymerized-type I collagen on mouse CIA. (a) Paw thickness in early arthritis model. One hundred microliters of Polymerized Collagen, 100 μL of Polymerized Collagen, and 100 μL of methotrexate (2.5 mg/kg) or 100 μL of methotrexate (2.5 mg/kg)/Polymerized Collagen were administered intramuscular once a week during 6 weeks at the same time of that of the booster. Citric/citrate buffer was injected as a vehicle control. Data represent mean ± SEM (each group, n = 6). (b) Clinical arthritis score in early arthritis model (n = 6). (c) Paw thickness in established arthritis model. One hundred microliters of Polymerized Collagen, 100 μL of Polymerized Collagen, and 100 μL of methotrexate (2.5 mg/kg) or 100 μL of methotrexate (2.5 mg/kg)/Polymerized Collagen were administered intramuscularly once a week during 6 weeks. Treatments were started on 14 days after the booster. Citric/citrate buffer was injected as a vehicle control. Data represent mean ± SEM (each group, n = 6). (d) Clinical arthritis score in established arthritis model (n = 6). *P < 0.05.