Table 2.
Mapuche medicinal plant extracts tested in sheep blood. The agonists are ADP (5.0 μM) and collagen (5.0 μg/mL) and the obtained aggregations are shown in percentage. Extracts are tested in 0.1 mg/mL end concentrations. The aggregation is shown for both extract and vehicle control. If the extract aggregation is 20% lower than that of the vehicle control inhibition is observed.
| Plant | Extract | Extract Yield (% dw) | Agonist | % Aggregation (extract) | % Aggregation (vehicle control) | % Inhibition | Inhibition |
|---|---|---|---|---|---|---|---|
| Amomyrtus luma (leaf) | DCM : MeOH 1 : 1 | 6.8 | ADP | 47 | 88 | 47 | Yes |
| Collagen | 25 | 85 | 71 | Yes | |||
| MeOH | 14.4 | ADP | 61 | 60 | −2 | No | |
| Collagen | 30 | 83 | 64 | Yes | |||
| H2O | 6.7 | ADP | 45 | 68 | 34 | Yes | |
| Collagen | 23 | 86 | 73 | Yes | |||
|
| |||||||
| Anthoxanthum utriculatum (leaf) | DCM : MeOH 1 : 1 | 5.2 | ADP | 38 | 49 | 22 | Yes |
| Collagen | 106 | 124 | 15 | *1 | |||
| MeOH | 4.9 | ADP | 33 | 68 | 51 | Yes | |
| Collagen | 22 | 77 | 71 | Yes | |||
| H2O | 4.8 | ADP | 50 | 51 | 2 | No | |
| Collagen | 39 | 75 | 48 | Yes | |||
|
| |||||||
| Blechnum chilense (leaf) | DCM : MeOH 1 : 1 | 2.8 | ADP | 52 | 62 | 16 | No |
| Collagen | 26 | 44 | 41 | Yes | |||
| MeOH | 1.8 | ADP | 38 | 52 | 27 | Yes | |
| Collagen | 1 | 18 | 94 | Yes | |||
|
| |||||||
| Cestrum parqui (leaf) | DCM : MeOH 1 : 1 | 7.6 | ADP | 49 | 81 | 40 | Yes |
| Collagen | 27 | 91 | 70 | Yes | |||
| MeOH | 3.7 | ADP | 44 | 77 | 43 | Yes | |
| Collagen | 30 | 83 | 64 | Yes | |||
| H2O | 15.9 | ADP | 73 | 82 | 11 | *1 | |
| Collagen | 52 | 82 | 37 | Yes | |||
|
| |||||||
| Corynabutilon vitifolium (leaf) | DCM : MeOH 1 : 1 | 3.6 | ADP | 48 | 54 | 11 | No |
| Collagen | 44 | 35 | −26 | No | |||
| MeOH | 3.7 | ADP | 39 | 59 | 34 | *1 | |
| Collagen | 48 | 49 | 2 | No | |||
|
| |||||||
| Fuchsia magellanica (leaf) | DCM : MeOH 1 : 1 | 12.2 | ADP | 45 | 45 | 0 | No |
| Collagen | 10 | 12 | 17 | No | |||
| MeOH | 6.2 | ADP | 30 | 52 | 42 | Yes | |
| Collagen | 32 | 38 | 16 | No | |||
|
| |||||||
| Gunnera chilensis (leaf + stem) | DCM : MeOH 1 : 1 | 13.1 | ADP | 50 | 59 | 15 | No |
| Collagen | 49 | 64 | 23 | Yes | |||
| MeOH | 3.3 | ADP | 40 | 56 | 29 | *1 | |
| Collagen | 35 | 65 | 46 | Yes | |||
| H2O | 6.5 | ADP | 50 | 71 | 30 | *1 | |
| Collagen | 68 | 56 | −21 | *1 | |||
|
| |||||||
| Lomatia ferruginea (leaf) | DCM : MeOH 1 : 1 | 2.7 | ADP | 24 | 55 | 56 | Yes |
| Collagen | 9 | 33 | 73 | Yes | |||
| MeOH | 1.1 | ADP | 43 | 50 | 14 | No | |
| Collagen | 6 | 55 | 89 | *2 | |||
| H2O | 6.9 | ADP | 57 | 43 | −33 | No | |
| Collagen | 30 | 50 | 40 | *1 | |||
|
| |||||||
| Luma apiculata (leaf) | DCM : MeOH 1 : 1 | 4.5 | ADP | 51 | 65 | 22 | *1 |
| Collagen | 42 | 75 | 44 | *1 | |||
| MeOH | 4.9 | ADP | 18 | 52 | 65 | Yes | |
| Collagen | 20 | 64 | 69 | Yes | |||
| H2O | 9.1 | ADP | 19 | 56 | 66 | Yes | |
| Collagen | 21 | 74 | 72 | Yes | |||
|
| |||||||
| Pluchea absinthioides (leaf) | DCM : MeOH 1 : 1 | 8.9 | ADP | 47 | 57 | 18 | *1 |
| Collagen | 17 | 39 | 56 | Yes | |||
| MeOH | 2.9 | ADP | 48 | 50 | 4 | No | |
| Collagen | 10 | 36 | 72 | Yes | |||
| H2O | 4.4 | ADP | 43 | 51 | 16 | No | |
| Collagen | 9 | 51 | 82 | *2 | |||
|
| |||||||
| Pseudopanax laetevirens (leaf) | DCM : MeOH 1 : 1 | 7.3 | ADP | 45 | 59 | 24 | Yes |
| Collagen | 23 | 61 | 62 | Yes | |||
| MeOH | 6.2 | ADP | 43 | 57 | 25 | *1 | |
| Collagen | 4 | 60 | 93 | Yes | |||
| H2O | 13.3 | ADP | 50 | 66 | 24 | Yes | |
| Collagen | 8 | 6 | −33 | No | |||
|
| |||||||
| Satureja multiflora (leaf + stem) | DCM : MeOH 1 : 1 | 7.2 | ADP | 44 | 74 | 41 | Yes |
| Collagen | 31 | 81 | 62 | *1 | |||
| MeOH | 7.1 | ADP | 60 | 67 | 10 | No | |
| Collagen | 44 | 125 | 65 | *1 | |||
| H2O | 14.3 | ADP | 61 | 64 | 5 | No | |
| Collagen | 11 | 43 | 74 | *2 | |||
*1: Aggregation curve and output % does not correlate, and the result is doubtful.
*2: Aggregation curve is very flat, this is suspicious.