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. Author manuscript; available in PMC: 2011 Oct 23.
Published in final edited form as: Oncogene. 2008 Sep 22;27(57):7192–7200. doi: 10.1038/onc.2008.356

Figure 4.

Figure 4

Effect of Id2 expression on the growth and metastasis of HCT-116 colon cancer cells in vivo. (a) Mean tumor volumes after subcutaneous injection of control (shRNA-control (sh-Con)) cells or clones with reduced Id2 expression. Bars indicate standard error of the mean for 10 mice. Volumes of both siRNA clones were different from the sh-Con control (P = 0.03 for sh-IdC14 and P = 0.017 for sh-Id2C15). (b) Average numbers of liver metastases after splenic injection of control (sh-Con) cells or clones with reduced Id2 expression. Bars indicate standard error of the mean for 10 mice. Both clones produced fewer metastases than did control cells (P = 0.022 for sh-Id2C14 and P = 0.045 for sh- Id2C15). (c) Mean volumes of metastases from control cells (sh-Con) and clones with reduced Id2 expression. Total volume is the sum of individual metastases in each liver. Data are means ± s.e.m. from 10 mice. Both clones produced lower volume metastases than did control cells (P ≤0.02). Id2, inhibitor of DNA-bind-2; siRNA, small interfering RNA.