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. Author manuscript; available in PMC: 2012 Oct 4.
Published in final edited form as: Biochemistry. 2011 Sep 6;50(39):8497–8507. doi: 10.1021/bi2012355

Figure 6.

Figure 6

Active sites of the hydrophobic pocket mutants liganded with azaUMP. The red spheres represent water molecules. All of the active sites contain two spatially conserved water molecules; the active sites of L123S and V155S contain an additional water molecule hydrogen bonded to the OH group of Ser 123.