Scheme 3.
Reaction conditions: i) NBS/AIBN/CCl4; ii) NaN3/DMSO; iii) R1C≡ CH/Sodium ascorbate/CuSO4/t-BuOH:H2O(1:1) or CuI/DMSO; iv) TBAF/THF; v) NaCN/DMSO; vi) NaN3/NH4Cl/DMF/100 °C; vii) CH3I/TEA/ACN; viii) CDI/THF/ACN.
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