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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Gastroenterology. 2011 Jun 25;141(5):1897–1906. doi: 10.1053/j.gastro.2011.06.051

Figure 3. IL-22 neutralization reduces liver inflammation and pathology following transfer of immunized splenocytes.

Figure 3

(A) Representative sections of liver from control HBV Tg mice given splenocytes from non-immunized mice (upper panels), immunized splenocytes alone (middle panels) and with anti-IL-22 Ab (lower panels) at day 2 (left) and day 5 (right) post administration. The overall morphology of control livers (upper panels) was normal. Mice with HBV-specific splenocyte induced hepatic injury alone had more frequent foci of necrotic hepatocytes (arrowheads) and inflammation (asterisks) at day 5 (middle right panel) than day 2 (middle left panel). Mice with HBV-specific splenocyte induced hepatic injury given anti-IL-22 Ab had fewer foci of necrosis and inflammation (lower panels) than mice not given anti-IL-22 Ab. Scale Bars = 50 microns. (B) Histopathology scores for necrosis and inflammation were significantly reduced at day 5 in anti-IL-22 treated mice.