Figure 3. PKCε antisense inhibits NLB-induced hyperalgesic priming in muscle.
In adult NLB rats that had received ODN antisense against PKCε for 3 days (filled circles, n=10), PGE2–induced hyperalgesia in the gastrocnemius muscle returned to baseline by 4 h post PGE2, while in mismatch-treated rats (open circles, n=10), PGE2 hyperalgesia remained elevated 24 h after PGE2.