Table 1.
Baseline Characteristics According to FGF-23 Tertile
| Variable | FGF-23 Level (RU/ml) | P-value Across Tertiles | ||
|---|---|---|---|---|
| < 37.9 (♀) | 37.9 – 82.4 (♀) | > 82.4 (♀) | ||
| <32.4 (♂) | 32.4 – 53.8 (♂) | > 53.8 (♂) | ||
| No. of Participants | ||||
| Men | 271 | 267 | 269 | |
| Women | 61 | 61 | 60 | |
| Age (years) | ||||
| Men | 67 ± 10 | 67 ± 10 | 68 ± 12 | 0.6 |
| Women | 65 ± 12 | 65 ± 10 | 63 ± 11 | 0.5 |
| Race | ||||
| Men | 0.02 | |||
| Caucasian | 169 (62) | 161 (60) | 178 (67) | |
| African-American | 36 (13) | 32 (12) | 46 (17) | |
| Other | 66 (24) | 74 (28) | 43 (16) | |
| Women | 0.01 | |||
| Caucasian | 22 (36) | 38 (62) | 29 (48) | |
| African-American | 18 (30) | 8 (13) | 20 (33) | |
| Other | 21 (34) | 15 (25) | 11 (18) | |
| Diabetes | ||||
| Men | 56 (21) | 76 (29) | 77 (29) | 0.06 |
| Women | 20 (12) | 16 (26) | 23 (38) | 0.07 |
| Hypertension | ||||
| Men | 175 (65) | 200 (75) | 184 (69) | 0.04 |
| Women | 38 (62) | 45 (74) | 52 (87) | 0.009 |
| BMI (kg/m2) | ||||
| Men | 27.3 (24.7, 30.4) | 27.7 (25.0, 31.4) | 27.1 (14.4, 30.4) | 0.5 |
| Women | 27.8 (25.4, 30.3) | 29.8 (24.9, 34.3) | 29.9 (26.3, 35.5) | 0.04 |
| eGFR (ml/min/1.73m2) | ||||
| Men | 78 ± 19 | 73 ± 22 | 59 ± 22 | < 0.001 |
| Women | 89 ± 19 | 77 ± 21 | 60 ± 23 | < 0.001 |
| UACR (mg/g)* | ||||
| Men | 7 (4, 14) | 8 (5, 15) | 12 (6, 30) | < 0.001 |
| Women | 10 (5, 17) | 8 (5, 14) | 19 (11, 78) | < 0.001 |
| Serum Phosphorus (mg/dL)* | ||||
| Men | 3.5 (3.2, 3.8) | 3.6 (3.3, 4.0) | 3.6 (3.2, 4.1) | < 0.001 |
| Women | 3.8 (3.6, 4.1) | 3.9 (3.6, 4.3) | 4.2 (3.9, 4.7) | < 0.01 |
| TMP/GFR* | ||||
| Men | 2.97 (2.59, 3.37) | 2.99 (2.64, 3.43) | 2.93 (2.49, 3.32) | 0.2 |
| Women | 3.58 (3.13, 3.93) | 3.56 (3.06, 3.98) | 3.64 (2.88, 4.25) | 0.6 |
Continuous data are shown as mean ± SD or median (25th, 75th percentile); categorical data as number (%). Conversion factor for serum phosphorus in mg/dL to mmol/L, x0.3229.
Abbreviations and definitions: BMI= body mass index; eGFR = estimated glomerular filtration rate; TMP/GFR=renal tubular maximum reabsorption rate of phosphate relative to the glomerular filtration rate; UACR, urine albumin-creatinine rate; FGF-23, fibroblast growth factor 23
*
Evaluated by Kruskal Wallis test.