Table 1.

Publications describing modifications of non-proteinaceous tryptophan by nitrating agents

Starting Molecule	Nitrating Agent	Modifications	Detection Method	Reference
5mM L-Trp	0.8mM ONOO−	6-NO2-Trp, 5-NO2-Trp, 4-NO2-Trp, 7-NO2-Trp	HPLC/UV-Vis	[10]
10mM L-Trp	0.5–5mM ONOO−	6-NO2-Trp	HPLC/UV-Vis	[11]
	10mM ONOO−	6-NO2-Trp, 2 x-NO2-Trps, x-OH-Trp, N-formylkinurenine or dihydrotryptophan
Boc-Trp	1mM ONOO−	Oxindole, hydropyrroloindole, N-formylkinurenine	HPLC/UV-Vis	[12]
6mM N-Ac-L-Trp	33.4mM ONOO−	6-NO2-Trp, 4-NO2-Trp, 7-NO2-Trp, 1-NO-Trp, 1-NO2-Trp	HPLC/UV-Vis	[6]
	Gaseous ·NO2
	LPO/H2O2/NO2−
	HRP/H2O2/NO2−
	NO2+	6-NO2-Trp, 4-NO2-Trp, 7-NO2-Trp, 5-NO2-Trp
0.5mM N-Ac-L-Trp	0.5mM ONOO−	6-NO2-Trp, 1-NO-Trp, 1-NO2-Trp, N-formylkinurenine	HPLC/UV-Vis	[7]
	MPO/H2O2/NO2−	6-NO2-Trp, 1-NO2-Trp, N-formylkinurenine
	0.5mM SIN-1	1-NO-Trp, N-formylkinurenine
	0.5mM Angeli’s Salt
	0.5mM spermine NONOate	1-NO-Trp
250uM L-Trp	metMb/H2O2/NO2−	6-NO2-Trp, 4-NO2-Trp, 5-NO2-Trp	HPLC/UV-Vis	[15]
2mM N-Ac-L-Trp	Gaseous ·NO2	1-NO-Trp	UV-Vis and NMR	[13]
	NaNO2/CH3COOH
	0.5mM MAMA NONOate
	N2O3
L-Gly-L-Trp	NaNO2/HCl	1-NO-Trp	UV-Vis and MS	[16]