Table 2.
CORTEX | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
NE | DA | 5-HT | MHPG | DOPAC | HVA | 5-HIAA | MHPG/NE | DOPAC/DA | HVA/DA | 5-HIAA/5-HT | |
IVT VEH (N=6) | 0.254 ±0.011 |
1.045 ±0.113 |
0.985 ±0.063 |
0.558 ±0.031 |
0.170 ±0.006 |
0.264 ±0.019 |
0.710 ±0 951 |
2.032 ±0.112 |
0.162 ±0.028 |
0.218 ±0.016 |
0.679 ±0.071 |
IVT DSP4 (N=11) | 0.217 ±0.024 |
1.C52 ±0.176 |
0.840 ±0.071 |
0.467 ±0.098 |
0.145 ±0.019 |
0.236 ±0.031 |
0.637 ±0.102 |
1.768 ±0.314 |
0.175 ±0.0429 |
0246 ±0.050 |
0.772 ±0.181 |
HYPOTHALAMUS | |||||||||||
IVT VEH | 0.645 ±0.086 |
0.346 ±0.117 |
0.887 ±0.229 |
0894 ±0.116 |
0.094 ±0.030 |
0.153 ±0.036 |
1.369 ±0.140 |
1.474 ±0.220 |
0.311 ±0.082 |
0.535 ±0.111 |
1.139 ±0.065 |
IVT DSP4 | 0.693 ±0.075 |
0.387 ±0.082 |
1.205 ±0.089 |
0875 ±0.130 |
0.086 ±0.011 |
0.155 ±0.026 |
1.173 ±0.193 |
1.229 ±0.101 |
0.249 ±0.036 |
0.491 ±0.074 |
0.987 ±0.114 |
Contents of major monoamines and metabolites in frontal cortex and hypothalamus of mice previously injected ivt with saline or 75 ug dsp4. Concentrations are ng per mg of tissue.