Fig. 3.

The highest scoring network constructed through Ingenuity Pathways Analysis based on protein targets for carbonylation by HNE in liver mitochondria (grey objects, input) shows 33 proteins, a microRNA (MIR17) and a signaling molecule, oxygen. Protein-protein interactions from the network diagram are represented by single lines and proteins/compounds that regulate another protein are indicated by arrows. Solid or dashed lines indicate direct or indirect interactions, respectively. The various shapes represent different protein functions: enzyme (diamond), ligand-dependent nuclear receptor (rectangle lying on its side), transcription regulator (oval), kinase (inverted triangle), ion channel (dashed rectangle), transporter (trapezoid), protein complex (concentric circle) and other (circle).