Table 4.

Test scores stratified by CVD status and the results of linear regression analyses showing the relationship of CVD status with cognitive testing results in 200 patients without stroke

Cognitive Test/Component		Test Scores		Univariate		Parsimonious		Extended
		No CVD	CVD	Beta (95% CI)	p-value	Beta (95% CI)	p-value	Beta (95% CI)	p-value
Executive Score*		0.32 ± 0.92	−0.42 ± 0.85	−0.80 (−1.05, −0.55)	<0.001	−0.52 (−0.77,−0.27)	<0.001	−0.50 (−0.75, −0.25)	<0.001
Memory Score**		0.15 ± 1.0	−0.09 ± 1.07	−0.24 (−1.04, 0.56)	0.1	0.38 (−0.46, 1.22)	0.3	0.34 (−0.48, 1.16)	0.4
Mini-Mental State Exama		26.9 ± 2.7	26.5 ± 3.0	−0.4 (−1.2, 0.4)	0.4	0.4 (−0.5, 1.2)	0.4	0.3 (−0.5, 1.2)	0.4
Immediate Recall (Total)b		26.0 ± 7.3	22.9 ± 8.0	−3.1 (−5.3, −0.9)	0.006	1.2 (1.0, 1.4)	0.2	1.0 (−1.0, 3.0)	0.4
Immediate Recall (Trial 1)c		4.1 ± 1.5	3.8 ± 1.8	−0.3 (−0.8, 0.2)	0.2	0.4 (−0.1, 0.9)	0.09	0.5 (0.0, 0.9)	0.06
Short Delayed Recalld		5.4 ± 2.9	4.3 ± 3.2	−1.2 (−2.0, −0.3)	0.009	0.2 (−0.7, 1.0)	0.7	0.2 (−0.6, 1.1)	0.6
Delayed Recalle		5.0 ± 2.8	4.1 ± 2.9	−0.9 (−1.7, −0.1)	0.03	0.3 (−0.5, 1.1)	0.5	0.3 (−0.5, 1.0)	0.5
Recognitionf		21.6 ± 2.6	20.3 ± 3.3	−1.2 (−2.1, −0.4)	0.004	−0.2 (−1.1, 0.6)	0.6	−0.3 (−1.1, 0.6)	0.5
Block Designg		30.1 ± 11.2	22.1 ± 9.1	−8.0 (−10.9, −5.1)	<0.001	−4.8 (−7.5, −2.1)	0.001	−4.7 (−7.4, −2.0)	0.001
Digit Symbol Coding*		47.0 ± 18.5	32.9 ± 12.2	−14.1 (−18.8, −9.4)	<0.001	−5.0 (−9.1, −0.9)	0.02	−4.1 (−8.4, 0.2)	0.07
Trails Ah		49.5 ± 26.6	70.2 ± 40.1	20.8 (11.6, 30.0)	<0.001	10.0 (0.4, 19.6)	0.04	8.4 (−1.2, 18.0)	0.09
Trails Bi	Completion	122.5 ± 62.7	164.0 ± 61.9	70.2 (40.3, 100.0)	<0.001	30.5 (2.3, 58.6)	0.03	26.4 (−2.1, 54.9)	0.07
	% Non-Completion	15.2%	30.7%

Results are mean ± standard deviation. Individual test results represent number correct except Trails A and B which are reported in seconds required to complete the task. Component scores by definition have a mean of 0 and standard deviation of 1 for the population. Negative coefficients indicate that CVD is associated with poorer performance on all tests except Trails A and B. Parsimonious models adjust for age, education, sex and race, while extended models additionally adjust for

^*cause of ESRD and BMI;

^**diabetes, BMI, diastolic blood pressure, Kt/V, phosphorus and vascular access;

^acause of ESRD, BMI, Kt/V, and phosphorus;

^bdiabetes, BMI, diastolic blood pressure, and Kt/V;

^cBMI, systolic blood pressure, PTH and Kt/V;

^dBMI, systolic blood pressure, Kt/V, and phosphorus;

^eBMI, diastolic blood pressure, Kt/V, and phosphorus;

^fdiabetes, BMI, diastolic blood pressure, and Kt/V;

^gBMI;

^hVintage and Kt/V; and

ⁱCause of ESRD, BMI and Kt/V.