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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Pediatr Nephrol. 2011 Jun 22;27(8):1233–1247. doi: 10.1007/s00467-011-1938-2

Figure 1. Interstitial collagens I and III are major components of the interstitial scar.

Figure 1

The fibrillar interstitial collagens I and III contribute to the formation of the interstitial matrix scaffold in normal kidneys (upper right photomicrograph); both are greatly expanded and contribute to interstitial scar formation in chronically damaged kidneys (lower right photomicrograph). Kidney mRNA levels (graph) provide a reasonable estimate of synthesis rates, as transcription is considered the rate-limiting step in collagen production. The examples are data from the unilateral ureteral obstruction (UUO) model in C57BL/6 mice (reproduced from [2, 3] reproduced with copyright permission).