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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Pediatr Nephrol. 2011 Jun 22;27(8):1233–1247. doi: 10.1007/s00467-011-1938-2

Figure 10. Interstitial fibrosis flowing severe acute kidney injury (AKI).

Figure 10

Acute renal ischemia (induced in C57BL/6 mice by cross-clamping the renal artery for 30 minutes), followed by reperfusion, has been extensively investigated as a model of acute kidney injury. Similar to humans, it is increasingly appreciated that renal recovery may not be complete; it may lead to chronic tubulointerstitial damage. In the study that is shown, (reproduced from [87] with copyright permission), the contralateral kidney was removed at the time of ischemia induction and fibrosis was detected by Masson trichrome staining 30 days later.